Search results for "HDL function"
showing 4 items of 4 documents
Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study.
2020
Abstract Aims Physical activity has consistently been shown to improve cardiovascular health and high-density lipoprotein-cholesterol levels. However, only small and heterogeneous studies have investigated the effect of exercise on high-density lipoprotein functions. Our aim is to evaluate, in the largest observational study to date, the association between leisure time physical activity and a range of high-density lipoprotein functional traits. Methods The study sample consisted of 296 Spanish adults at high cardiovascular risk. Usual leisure time physical activity and eight measures of high-density lipoprotein functionality were averaged over two measurements, one year apart. Multivariabl…
STUDIES ON FACTORS INFLUENCING HIGH-DENSITY LIPOPROTEIN FUNCTIONALITY AND REVERSE CHOLESTEROL TRANSPORT
Coronary artery disease (CAD) in dyslipidemic and diabetic subjects remains the leading cause of death in the Western society. Current therapeutic strategies to prevent cardiovascular diseases are primarily based on the use of statins, which inhibit key enzyme in the cholesterol synthesis, HMG-CoA reductase. Another prominent risk factor for developing premature atherosclerosis is the low levels of high-density lipoprotein cholesterol (HDL-C). Despite documented benefits of statins a good proportion of individuals still remain at a higher risk of developing CAD. Therefore, focus has shifted on HDL-raising therapeutics to further improve the CV outcome. While Niacin and fenofibrate have not …
SUBFRACTIONS AND SUBPOPULATIONS OF HDL: AN UPDATE
2014
High-density lipoproteins (HDL) are classified as atheroprotective because they are involved in transport of cholesterol to the liver, known as "reverse cholesterol transport (RCT)" exerting antioxidant and anti-inflammatory activities. There is also evidence for cytoprotective, vasodilatory, antithrombotic, and anti-infectious activities for these lipoproteins. HDLs are known by structural, metabolic and biologic heterogeneity. Thus, different methods are able to distinguish several subclasses of HDL. Different separation techniques appear to support different HDL fractions as being atheroprotective or related with lower cardiovascular (CV) risk. However, HDL particles are not always prote…